Inhibition of Cerebral Vasoconstriction by Dantrolene and Nimodipine
نویسندگان
چکیده
منابع مشابه
The inhibition of acetylcholinesterase by dantrolene and ondansetron.
PURPOSE A virtual screening study has suggested that the skeletal muscle relaxant, dantrolene, and the antiemetic drug, ondansetron, may act as inhibitors of the enzyme acetylcholinesterase (AChE). Based on this proposal, the current study examines the AChE inhibitory properties of these drugs. METHODS AND FINDINGS Using AChE from human erythrocytes as enzyme source, it is shown that dantrole...
متن کاملEssential Role of Calmodulin in RyR Inhibition by Dantrolene.
Dantrolene is the first line therapy of malignant hyperthermia. Animal studies suggest that dantrolene also protects against heart failure and arrhythmias caused by spontaneous Ca(2+) release. Although dantrolene inhibits Ca(2+) release from the sarcoplasmic reticulum of skeletal and cardiac muscle preparations, its mechanism of action has remained controversial, because dantrolene does not inh...
متن کاملEssential Role of Calmodulin in RyR Inhibition by Dantrolene s
Dantrolene is the first line therapy of malignant hyperthermia. Animal studies suggest that dantrolene also protects against heart failure and arrhythmias caused by spontaneous Ca release. Although dantrolene inhibits Ca release from the sarcoplasmic reticulum of skeletal and cardiac muscle preparations, its mechanism of action has remained controversial, because dantrolene does not inhibit sin...
متن کاملReversible cerebral vasoconstriction syndrome induced by adrenaline.
INTRODUCTION Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by acute severe thunderclap headaches and evidence of multifocal, segmental, reversible vasoconstrictions of the cerebral arteries. Several precipitating factors have been identified and reported, including the use of recreational substances or sympathomimetic drugs and the postpartum state. CASE DESCRIPTION He...
متن کاملReversible cerebral vasoconstriction syndrome.
Reversible cerebral vasoconstriction syndrome (RCVS) is an under-recognised condition. It is characterised by sudden and severe headaches (of "thunderclap" type) associated with multifocal reversible narrowing of the intracranial arteries on neuroradiology. The diagnosis is often established with the resolution of headaches and vasoconstriction. We report two patients with RCVS and review the a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurocritical Care
سال: 2008
ISSN: 1541-6933,1556-0961
DOI: 10.1007/s12028-008-9153-0